Monthly Archives: February 2014

Flagyl (Metronidazole) – antimicrobial and antiprotozoarians drug

Flagyl – Metronidazole is an antimicrobial and antiprotozoarians drug for systemic use. It’s used in the prophylaxis and treatment of infections caused by anaerobic bacteria. Flagyl operates on a wide variety of anaerobic microorganisms in particular strains of Bacteroides, Fusobacteria, Clostridia, Eubacteria, Peptococcus, Peptostreptococcus i Gardnerella vaginalis. Also efficient is within infectious caused by Trichomonas, Entamoeba histolytica, Giardia lamblia i Balantidium coli.

Flagyl pills are applied in the following states: prevention of post-operative infections caused by anaerobic bacteria, sepsis and bacteremia, abdominal infections, pseudomembranous colitis caused by Clostridium difficile, active phase of Crohn’s disease, gastritis and peptic ulcer caused by Helicobacter pylori, urogenital trichomoniasis in women and men, bacterial vaginitis , amoebiasis and Lambliasis, infections of skin and soft tissue , bone and joint infections lower respiratory tract infections (pneumonia, empyema, and lung abscess).

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Contraindications

Flagyl pills may not be used in case of hypersensitivity to metronidazole. Patients, who are taking higher doses, should be clinically monitored. Taking metronidazole may have a slight effect on the value of AST, ALT, LDH, and triglycerides. As with other drugs, the use of metronidazole is not recommended during pregnancy or breastfeeding, unless your doctor deems necessary.

Dosage

  • In anaerobic infections: adults and children over 10 years: 800 mg first dose, then 400 mg every 8 hours. Urogenital trichomoniasis- medicates both partners simultaneously. Bacterial vaginitis-is administered as a one-day therapy in a dose of 2 grams once, or like week therapy in a dosage of 400-500 mg of 2 times per day.
  • Pseudomembranous colitis caused by Clostridium difficile- Flagyl is administered at a dose of 1-2 g / day, for 7-10 days.
  • Crohn’s disease- Flagyl pills is administered at a dose of 500 mg / day with a particular effect on the improvement of perianal events.

Side effects

There may be a lack of appetite, nausea; vomiting, diarrhea or constipation, very rarely can occur dizziness, vertigo, ataxia, confusion, hallucinations, psychosis, and impaired coordination of movements, transient visual disturbances (diplopia, myopia), headache and drowsiness. It is possible occurrence of dysuria, cystitis, and rarely dark brown urine for excreted metabolites. Very rarely are reported cases of agranulocytosis, neutropenia, thrombocytopenia and pancytopenia, which are usually drawn upon discontinuation of therapy. Very rarely, but it can, cause abnormal liver enzymes, cholestatic hepatitis and jaundice who withdraw after discontinuation of therapy. Hypersensitivity reactions to metronidazole may be revealed urticaria, angioedema, drug eruption, rarely anaphylaxis may occur, and rash but rarely. Despite its wide range of activities, should be cautious in applying Flagyl tablets, and when there are occurred any complications, you should call your doctor for consultation, or for changing treatment.